Hunan Xeno Life Science Incorporated Company (XLS, 836907) was established in Changsha, Hunan in March, 2008. Our main business scope is to research, develop and produce cell xenotransplantation products, we have a high-level research team including 27 staffs (6 staffs with PhD. research background and all staffs with biomedical research background), and the XLS is a Joint Lab of the Hunan Technique Research Center for xenotransplantation engineering, which includes DPF Donor Pig Breeding Center for xenotransplantation, Cell Resource Bank, Research Lab and a Specialist Hospital for diabetes. Moreover, we partnered with the Cell Transplantation and Gene Therapy Research Institute of Central South University in xenotransplantation field.

Currently, the XLS covers 8.24 acres land of Xiangjiang New Area, the national high-tech zone in Changsha. We also invested 60 million RMB and established the first medical grade DPF donor pig breeding center in Asian-Pacific region that meets the World Health Organization (WHO) standards and with self-owned intellectual property in August, 2012. Meanwhile, the XLS set up cGMP standard cell preparation and production center, which initially covered the integrated industrial chain from breeding and raising medical grade donor pigs to the production and preparation of donor cells as well as the standard setting and management. It also includes preclinical studies, clinical applications and the developments of transplantation techniques. Along with our own ‘Xeno I’–branded xenotransplantation donor pigs, we also own all core techniques and intellectual property of ‘Porcine Islet Diabetes Treatment’. Furthermore, the XLS is working on the preclinical research of neurocytes xenotransplantation for Parkinsonism therapy and the preliminary study of humanized pigs (transgenic pigs, the ‘Xeno II’)

The DPF donor breeding, along with the research and industrialization of pig islet xenotransplantation project of the XLS was listed in ‘2014 Major Science and Technology Projects of Hunan Province’. The XLS also received a specific grant of RMB 446 million Yuan and was strongly supported by government sectors.

Based on our early efforts for nearly 20 years, the XLS research team has already set up the inbred line of donor pigs that is suitable for islet xenotransplantation and conforms to international standards, which holds fully independent intellectual property. The inbred population of donor pigs (Xeno I) bred by us have the following characteristics: ①The deficiency of Porcine Endogenous Retrovirus C (PERV-C); ② On account of the strong ability of its islet basement membrane to resist digestive enzyme, the yield rate of extracting porcine islet is 21% higher and the viability of depurated porcine islet is 8% higher than those of other pig breeds. The establishment of this germ line marks that the level of Chinese breeding xenotransplantation donors has reached the basic requirements of WHO.

According to the relevant criteria and requirements of WHO and through synthesizing the suggestions made by international and Chinese counterparts, the XLS has set up the breeding system of biological security barrier for DPF pigs, including the architectural structure, the techniques of feed proportion, asepsis feed and animal breeding as well as management practices. The donor pigs from the XLS DPF breeding center conforms to the standard of DPF medical donor pigs’ microbiology inspection project, which was tested by National Institutes for Food and Drug Control, the most professional and authoritative testing institutes in China. This pig breed is the only one that accords with the DPF standard testing. Meanwhile, there are three advantages of the islet cell preparations separated and purified by the XLS Cell Preparation Center: high activity, high purification and high yield rate.

Currently, the XLS owns 7 Chinese national invention patents.

The establishment and application of the XLS DPF Donor Pigs Breeding Center is a significant event in the field of international xenotransplantation, which was featured byXenotransplantation, the official publication of the International Xenotransplantation Association (IXA).