Islet cell transplantation is the only reliable treatment technique to prevent the complications of diabetes. The principle of porcine islet transplantation in the treatment of diabetes is very simple, you can restore the glucose metabolism in diabetic patients with stable. The transplanted porcine islet cells (including B cells, A cells, etc.) can regulate the secretion of insulin, glucagon and other hormones according to physiological needs, which can prevent hyperglycemia and prevent hypoglycemia. The secretion of insulin is a physiological secretion, which is not achieved by any diabetes intensive treatment program. This technology will become the terminator of diabetes in the future. Porcine islet transplantation for patients with type 1 diabetes will restore a healthy pancreas, in patients with type 2 diabetes, insulin resistance and beyond.


The latest version of the US global diabetes authority Joslins Diabetes Mellitus (Fourteenth Edition) has been applied to treat diabetes in islet transplantation as follows.



Although B cell replacement is generally considered to be an effective way to treat type 1 diabetes, many people think that the most important problem in type 2 diabetes is insulin resistance, and insulin deficiency only plays a part in its pathogenesis. But they do not realize that B cell replacement is an effective way to treat type 2 diabetes. People who hold a partial role of insulin deficiency in their pathogenesis do not realize that only when islet B cells are unable to compensate for insulin resistance, will this happen to diabetes? In order to better understand the function of islet B cells, we must recognize that: because islet B cells can compensatory increase in insulin secretion, with the vast majority of patients with insulin resistance will still be able to maintain the normal level of blood glucose, so B cell failure occurred in the process of type 2 diabetes has played a key role in the.



Some people think that the treatment of type 2 diabetes need to accept a large number of islet cells so that the expensive price prohibitive, and the resulting hyperinsulinemia and will result in patients with vascular disease. But in fact, the demand for insulin in many type 2 diabetic patients is not significantly different than that in type 1 diabetes. Because the latter still has some remaining islet cells that can secrete insulin. Besides, once a simple acquisition method of insulin secreting cells has been solved, a large number of transplanted islet cells will be overcome. The health benefits of islet transplantation are very great for patients with type 2 diabetes, such as the prevention of microvascular complications and neurological complications. We also have many reasons to believe that it can also reduce the incidence of cardiovascular events. Although insulin resistance and central obesity are still present in patients with type 2 diabetes after receiving islet transplantation, there are much fewer complications compared with those with diabetes mellitus. Although there are many ways to help some problems of diabetes, such as the use of new drugs to improve insulin resistance, weight loss drugs and so on, islet transplantation can provide most of the benefits. Thus, B cell replacement therapy can prevent the occurrence of hyperglycemia related complications in most types of diabetic patients. In fact, many non type 1 diabetes mellitus is more suitable for B cell replacement therapy, because the implanted islets only need to overcome allograft rejection, and do not need to overcome autoimmune as well as type 1 diabetes.