Fragile diabetes? High-risk!

Release time: 2017-11-3 16:32:55 Page views: 276

Fragile diabetes? High-risk!

2017-11-03 biological and xenotransplantation
You know all of type 1 diabetes, type 2 diabetes, and gestational diabetes - but do you know what is called "fragile diabetes"?

Brittle diabetes is not a new type of diabetes. It refers to diabetes that is unstable, hyperglycemic and hard to control. It is also known as "unstable diabetes".

In the past, brittle diabetes was mostly attributed to type 1 diabetes. In fact, "brittle diabetes" is also seen in some patients with type 2 diabetes who are almost failure of islet function.

"Brittle" diabetes "is named according to its clinical characteristics," brittle "as the name suggests, it is not easy to control blood glucose fluctuation, prone to hypoglycemia and ketoacidosis, the characteristics of polarization phenomenon, because their blood sugar is completely dependent on exogenous insulin to regulate. (focus!!!)

How to self test is not "fragile diabetes"


Generally, there are 3 clinical features of fragile diabetes:

1, the patient is usually thinner, the islet function is very poor or close to exhaustion.

2, the patient‘s condition is very unstable. Even when the amount of food, exercise volume and insulin dose are almost constant, blood sugar will also have inexplicable significant fluctuations, especially prone to hypoglycemia, ketoacidosis and even coma.

3, it is very sensitive to the regulation of insulin injection dose. When blood sugar is increased, a slight increase of insulin injection (such as 2 units) occurs hypoglycemia, and when blood sugar drops, a slight decrease of insulin dose and blood glucose increase.

Of course, in addition to seeing whether there is a large blood sugar fluctuation and prone to hypoglycemia symptoms, it is more scientific to diagnose whether they have brittle diabetes.

The treatment of fragile diabetes

The greatest harm of fragile diabetes is the occurrence of severe or even irreversible hypoglycemic coma.

A serious hypoglycemic event can counteract the benefits of a lifetime of blood sugar.

In addition, the blood glucose fluctuation of brittle diabetes is very large. Frequent hypoglycemia and hyperglycemia (blood glucose fluctuation) can accelerate arteriosclerosis and increase the incidence and mortality of cardiovascular events in diabetic patients. So the treatment of patients with fragile diabetes is very difficult.


(the harm of fragile diabetes)

At present the treatment of brittle diabetes mainly rely on insulin therapy, insulin pump based on a precise set of pump infusion rate and pre meal bolus infusion, to provide the best to simulate physiological insulin secretion of insulin infusion, allowing patients blood glucose control is relatively stable.

But even this does not prevent the disease from continuing to develop.

Islet transplantation is an effective treatment for type I diabetes mellitus, especially fragile diabetes, which has been developed in recent years. It has the advantages of simple operation, small trauma and good treatment effect.

After islet transplantation, we can make up for the loss of islet function, improve the fragile diabetes state, stabilize the glucose metabolism, control the blood sugar of the patients well, and achieve the curative effect of curing diabetes.

However, due to the extreme shortage of human donor organs is a worldwide problem that cannot be solved. Especially in China, more than 99% of the patients can not get effective treatment, and in order to maintain life, they have to spend huge amounts of medical expenses.

Porcine islet transplantation therapy -- a revolutionary


(the site of the review conference)
In September 8, 2017, Hunan Province Medical Association national top experts (Chairman of the endocrine society, led the National Diabetes Association chairman, chairman of Changsha transplantation society etc.) in the Third Xiangya Hospital of Central South University and the No. 1 DPF sainuo zaino biological pig as donor, jointly complete the "new" pig islet transplantation in the treatment of type 1 diabetes clinical research conducted a comprehensive evaluation.

The group of experts agreed that: twenty years after the project team to persevere, for the first time in the world established donor culture of porcine islet extraction and clinical application of integrated technology system, has reliable biocompatibility, made the islet xenograft the best curative effect, can be used in the treatment of type 1 diabetes. Reached the international advanced level.

The expert group recommends that the technology of heterologous islet transplantation for the treatment of diabetes is included in the three category of medical technology management, and the corresponding clinical application technical specification is formulated, so as to promote the clinical application of the technology.

In the future, the cure of fragile diabetes will not be a dream!