The Largest Pork Producer around the World Marches into Xenotransplantation

Release time: 2017-7-10 13:43:00 Page views: 348

The World‘s Largest Pork Producer Marches into Xenotransplantation

2017-07-10 Xeno Life and xenotransplantation
Like the production of sausage as "production" to supply the human organs for transplant?

The plot in those science fiction films is becoming a reality.

 

 

(Smith Field food company)
The day before, the world‘s largest pork producer Smith Rumsfeld food company announced that they set up a separate unit of biological science, specifically to provide pig organs for medical treatment, hoping to form for human transplantation of pig organs production chain, and thus to fill the vacancy of human organ donation, provide a way for organ transplant patients.

Coincidentally, the news shortly after the release of the domestic main xenotransplantation research team and scientists gathered in Beijing, held a key scientific problem to study clinical xenotransplantation as the theme of the 593rd Xiangshan Science Conference, together with the trend of the clinical research on China‘s current situation of the development of xenotransplantation and how to speed up.

(A photo of the experts in the Xiangshan Conference)


Shortage of donor is the bottleneck of organ transplantation

According to data published by the WHO, the world‘s demand for organs is far greater than the supply of organs. As the number of donors is extremely scarce, most patients are unable to receive treatment.

Lack of organ transplantation is still a worldwide problem. Even in the United States with high organ donation rate, there will be a new organ transplant patient every 10 minutes. According to the US organ sharing network, an average of 22 people are waiting to die in organ transplants every day. The shortage of donor organs is one of the main bottlenecks that restrict the development of organ transplantation.

Pig is the best organ donor found at present

In its clinical research specification on xenotransplantation, WHO pointed out that pigs may become an unlimited number of high-quality organ, tissue and cell donor resources. The organs, such as kidneys, hearts, islets and nerve cells of pigs, are almost identical with human organs, tissues and cells in structure and function. They can replace human organ donors from structure and function.

More importantly, pigs can also be genetically modified to improve the therapeutic effect of xenotransplantation.

 

(Xenograft donor pigs)

Anti rejection therapy is the key to the clinical application of xenotransplantation

The chairman, the Third Xiangya Hospital of Central South University professor Wang Wei said the implementation of Xiangshan conference, immune rejection, physiological function of incompatible and animal pathogens cross species infection is a major barrier to xenotransplantation.

The international consensus that xenograft transplantation, by genetic modification, humanized genetic modification of donor pigs, is expected to control the immune rejection and the function of incompatible problem, can significantly improve the xenogeneic organs, tissues and cells transplanted into the body of the treatment effect, reduce the use of anti rejection drugs.

The research on xenotransplantation in China is in the lead

Due to the increasing investment in the field of xenotransplantation in recent years, there are transplanting teams in the US, China, Japan, Korea and Australia. The experimental records are refreshed again and again.

The recipient‘s survival time has been 945 days after a xenotransplantation from Massachusetts General Hospital.

China from Xijing Hospital of The Fourth Military Medical University team completed pig liver transplant surgery to experiment in vivo liver and Tibetan macaque, the longest survival receptor for 25 days;
......

The survival time of xenotransplantation and tissue transplantation is significantly longer than that of solid organ transplantation. Professor Wang Wei said that in 1999 the Central South University team won government approval, on 22 cases of patients with type 1 diabetes of neonatal porcine islet transplantation, including 20 cases of patients after transplantation, blood sugar stable, obvious reduction of exogenous insulin, glycosylated hemoglobin returned to normal, 6 years after the review found no cross species infection.

 

(Professor Wang Wei in a xenotransplantation laboratory)

Although China in xenotransplantation research field in the international first-class ranks, but the experts agreed that, to maintain the leading trend, the national needs and researchers to work together in the policy, research funding and research power have more input to.

Xenotransplantation, though facing many difficulties at present, has reached an important moment for a breakthrough. As ThomasE.Starzl, the father of liver transplantation, said, "any technology may seem incredible yesterday, but today it seems to be barely able to do it, but tomorrow it may become a conventional way."

》》》medical grade donor pig《《《
2012
Xeno Life established medical grade with WHO xenograft standard clinical research "(DPF) donor pig breeding base and islet preparation center", to become the world‘s second medical grade outside the United States (DPF) donor pig breeding center.
Xeno Life through ten years of efforts to develop the Sino pig inbred line deletion of porcine endogenous retrovirus C strain, and very stable, so as to solve the risk of porcine endogenous retrovirus infection.

2015
Central South University in cooperation with the Sino biological "key technology of bio safety and xenogeneic transplantation model" by the national multidisciplinary group of experts identified, the project has reached the international advanced level, won the 2015 annual Hunan Province technological invention award.
Identified by the authoritative testing organizations - China Research Institute of food and drug inspection detection: no specified pathogen donor pigs zaino biological barrier environment construction, technological route and standardized management of cultivated with WHO (DPF) detection standard of pigs, to become China‘s first in line with the DPF standard pig donor pigs.

2016
The expert group review review, agreed that: Sino biological research and development project in China established successfully for the first time can effectively control acute rejection after xenotransplantation of alpha -galKO+hCD55+hCD59 humanized DPF gene modified pigs - Shiner No. 2, provide experimental animal strains for cell and organ transplantation preclinical and clinical research, reached the international advanced level.

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